Photo by National Cancer Institute on Unsplash
Bio Information is Energy
Cognano is a venture that aims at computer-aided drug discovery. Utilizing large VHH data obtained from alpacas, we are developing a new drug discovery platform to optimize drug design and development. We are actively seeking development partners for our newly identified cancer-specific antigens and antibody drugs. Our focus areas include:
- Triple-negative breast cancer (TNBC)
- Pancreatic cancer
- Small cell lung carcinoma
12Years
Research on VHH Antibodies
50Types
Antigens
300MReads
Antibody Genes
30MClones
Labeled Antibody Sequences
Photo by Who’s Denilo ? on Unsplash
Pitch
London Tech Week was held in June 2024. Six selected ventures from Japan exhibited, one of which was COGNANO. The following video is a pitch video made by the representative of COGNANO at London Tech Week. A blog post here.
VHH Antibody
For DNA organisms including humans, the genome should not change throughout our lives, but only the antibody genes change almost infinitely (hypermutation), and the acquired antibodies fight viruses, bacteria, and cancer. In this meaning, antibodies are amazing nature's masterpiece. Evolutionarily, it originated in cartilaginous fish such as the eight-eyed eel, then evolved into a more complex fo...
Projects
- Research Grant
- Research Grant
- Research Grant
- Certification
- Joint Research
- Research Grant
Blog
Synergy between immune response and machine learning
Vertebrates have the ability to make complex (full-bodied) antibodies composed of light and heavy chains, but only camelids have single-domain antibodies in addition to full-bodied antibodies. Single domain antibodies can be easily made into a gene library from lymphocyte genes, and antibodies created by immunized camelids will be big data.
Biopanning-labeled data using intermolecular interactions (antigen-antibody reactions) are integrated by COGNANO's unique algorithm, making it possible to predict the binding characteristics (binding affinity, epitope) to antigen molecules.COGNANO's original platform that can calculate antibody characteristics by machine learning huge amounts of real antibody data and provide them as seeds at high speed.
Even if the naive library, which is not immunized, is analyzed, it cannot be used as teaching data for machine learning because the number of types of binding antibodies is too small. Our Cognano VHH platform make it possible to discover target antibodies 10K times effectively compared with conventional mouse or human antibody platforms.